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观察乙型肝炎 (乙肝 )血源疫苗新生儿期接种 9～ 10年后 ,疫苗诱导抗体转阴者是否仍对乙肝表面抗原 (HBsAg)保持免疫记忆。采用RIA方法测定并比较乙肝疫苗加强免疫(加免 )前后受试对象的抗 HBs水平。结果 48名受试儿童加免后 1个月 ,抗 HBs阳性率与滴度均明显高于免前 (p <0 0 1) ,70 9% (34 /4 8)的加免儿童保持免疫记忆 ,持续时间至少已 3年。提示 3针 10 μg乙肝血源疫苗新生儿期接种 9～ 10年后 ,大部分诱导免疫抗体阴转的免疫儿童保持着免疫记忆。初免后 10年仍未见有加强免疫的必要
To observe whether hepatitis B (HB) vaccine still retains immunological memory of hepatitis B surface antigen (HBsAg) after 9-10 years of neonatal vaccination. The RIA method was used to measure and compare the anti-HBs levels of the subjects before and after boosting (boosting) with hepatitis B vaccine. Results The positive rate and titer of anti-HBs in 48 subjects were significantly higher than those in pre-immunization (p <0.01) and 70% (34/48) in immunized children For at least 3 years. Tip 3-pin 10 μg hepatitis B blood vaccine in the neonatal period of 9 to 10 years after vaccination, most of the immune-induced immune-immune children retain immune memory. Ten years after the first immunization, there is still no need to strengthen the immunization