在乙醇介质中,一水合磷酸西他列汀与红紫素在室温中放置15~30 min,二者可以形成1∶1型荷移络合物,其λmax为520nm,表观摩尔吸光系数为1.93×103 L/(mol·cm),线性范围为0.031~0.209g/L,线性回归方程为A=3.104 5C+0.144 2,相关系数R为0.999 1,相对标准偏差为1.32%(n=6)。实验结果用于捷诺维片含量的测定,结果满意。 In ethanol medium, sitagliptin phosphate monohydrate and purpurin at room temperature for 15 ~ 30 min, the two can form a 1: 1 charge-transfer complex, the λmax 520nm, the apparent molar absorptivity was The linear regression equation was A = 3.104 5C + 0.144 2, the correlation coefficient R was 0.999 1, the relative standard deviation was 1.32% (n = 6), the linear range was 0.031-0.209 g / L, and the linear range was 1.93 × 103 L / (mol · cm) ). The experimental results were used to determine the content of minocycline and the results were satisfactory.