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目的 探讨急性心肌梗死 (AMI)溶栓治疗不同时间一氧化氮 (NO)、一氧化氮合酶 (NOS)的变化及意义。方法 选择 1999年 1月 1日 - 2 0 0 1年 9月 30日间在本院住院符合AMI诊断标准及溶栓指征的患者。共 2 8例 ,男 2 0例 ,女 8例 ,年龄 (5 9.78± 6 .6 7)岁 ;对照组 10例 ,年龄 (5 7.6 7± 5 .34)岁。取静脉血测定NO、NOS浓度。结果 (1)AMI组在溶栓前NO、NOS浓度较对照组高 ,差异有显著性 ;(2 )与对照组比较 ,溶栓后无论血管再通与否 ,各时间窗NO、NOS均高于正常值 ,差异有显著性 ;(3)再通组较对照组NO、NOS高 ,但仅在 0 .5h、3h有显著性差异。结论 NO、NOS在AMI发生后升高 ,溶栓治疗后仍高于正常 ,持续时间较长 ,可能为机体的一种反馈性保护机制。溶栓可以改善血管内皮功能。
Objective To investigate the changes and significance of nitric oxide (NO) and nitric oxide synthase (NOS) in acute myocardial infarction (AMI) thrombolytic therapy at different time points. Methods From January 1, 1999 to September 30, 2001 in our hospital in line with AMI diagnostic criteria and indication for thrombolytic patients. A total of 28 cases, 20 males and 8 females, age (5 9.78 ± 6.67) years old; control group of 10 patients, age (5 7.67 ± 5.34) years of age. Take venous blood to determine NO, NOS concentration. Results (1) The concentrations of NO and NOS in AMI group were significantly higher than those in control group before the thrombolysis. (2) Compared with the control group, NO and NOS in each time window were higher regardless of recanalization after thrombolysis In the normal value, the difference was significant; (3) Recanalization group than the control group NO, NOS high, but only at 0 .5h, 3h significant difference. Conclusions NO and NOS increased after AMI, and remained higher than normal after thrombolytic therapy for a long time, which may be a kind of feedback protective mechanism for the body. Thrombolysis can improve endothelial function.