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该试验模拟胰岛素抵抗时空腹的代偿性高胰岛素血症,研究中等程度高胰岛素血症对肱动脉和股动脉的内皮细胞依赖性血管舒张的影响。 方法 年龄在20～29岁不抽烟的健康志愿者25名。研究由两部分,四个试验组成。第一部分:胰岛素和生理盐水对照。A试验:低浓度胰岛素(110pmol/L)与生理盐水比较。9名受试者参加,在1～8周内先后接受两次试验,每次持续450min。试验前90min测量心率、血压和左肱动
The trial modeled fasting compensatory hyperinsulinemia during insulin resistance and investigating the effects of moderate hyperinsulinemia on endothelial-dependent vasodilatation of the brachial and femoral arteries. Methods Twenty-five healthy volunteers aged 20-29 years without smoking were enrolled. The research consists of two parts and four experiments. The first part: Insulin and saline control. A test: low concentration of insulin (110pmol / L) compared with saline. Nine subjects participated and took two trials one to eight weeks in succession, each lasting 450 minutes. 90min before the test heart rate, blood pressure and left brachial motion