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目的观察A型肉毒毒素治疗带状疱疹后神经痛的临床疗效和不良反应。方法重度带状疱疹后神经痛患者29例,应用A型肉毒毒素进行皮内注射治疗,问卷调查记录每例带状疱疹后神经痛患者治疗前、治疗后1,2,4,8周带状疱疹后神经痛疼痛严重程度,观察不良反应。结果A型肉毒毒素治疗后1周,带状疱疹后神经痛疼痛严重程度均较治疗前明显下降(P<0.01),疗效可至少维持8周,且不良反应轻微、短暂。结论A型肉毒毒素皮内注射治疗带状疱疹后神经痛临床疗效显著,不良反应轻微、短暂,值得临床研究。
Objective To observe the clinical efficacy and adverse reactions of botulinum neurotoxin A in the treatment of postherpetic neuralgia. Methods Twenty-nine patients with severe post-herpetic neuralgia were treated with botulinum toxin type A for intradermal injection. The questionnaires were recorded before treatment, 1, 2, 4, 8 weeks after treatment in patients with post-herpetic neuralgia Postherpetic neuralgia pain severity, observed adverse reactions. Results One week after the treatment with botulinum toxin A, the pain severity of postherpetic neuralgia was significantly lower than that before treatment (P <0.01). The curative effect was maintained for at least 8 weeks with mild and transient adverse reactions. Conclusion Intradermal injection of botulinum toxin type A has obvious curative effect on post-herpetic neuralgia with slight and short-term adverse reactions, which deserves clinical research.