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申请人:中国药科大学发明人:刘静涵、后德辉、王秋娟、张陆勇、赵守训、范炳尧一、立项背景我国中草药资源丰富,目前已知具有抗心律失常活性的生物碱众多,所以以中草药有效成分为先导物进行结构修饰是寻找新型抗心律失常药的有效途径之一。我国唐代《证类本草》记载白附子(令称关白附)主治心痛血痹,我们从发掘提高祖国医药学和新药开发研究出发对传统中药关白附(毛茛科黄花乌头Aconitum coreanum(Lévl.)Rapaics)块根进行化学、药理学、毒理学研究。我们从中分离得到多
Applicant: Inventors of China Pharmaceutical University: Liu Jinghan, Hou Dehui, Wang Qiujuan, Zhang Luyong, Zhao Shouxun, Fan Bingyi 1. Background of Chinese herbal medicine resources are abundant in China. There are many alkaloids known to have antiarrhythmic activity so that active ingredients of Chinese herbs are used. Structural modification of the lead is one of the effective ways to find new antiarrhythmic drugs. In the “Toxic Herbal Medicine” of the Tang Dynasty in China, the records of Baifuzi (called Guan Baifu) were referred to as heartache and blood stasis. We started from the research on improving the medical science and new drug development in the motherland. The traditional Chinese medicine Guanbaifu (Aconitum coreanum Lévl.) Rapaics) Root tube for chemical, pharmacological, toxicological studies. We separated from it