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目的：对小儿肝功能异常的发生病因、临床表现及不同程度肝功能异常的治疗效果进行探讨。方法对120例肝功能异常的患儿的临床资料进行回顾性分析。结果导致小儿肝功能异常原因较多，病毒感染是最主要的发病原因，有42例，细菌感染28例，支原体感染16例，川崎病8例，药(毒)物损害8例，药(毒)物损害有毒鼠强、毒蘑菇、中草药、头孢曲松钠、丙戊酸钠等；遗传代谢性疾病8例，其他原因有10例。患儿临床表现不十分明显，少有呕吐、腹泻、恶心、厌食、腹水、黄疸等出现；轻度肝功能异常患儿23例痊愈，16例好转，1例无效；中度患儿里38例痊愈，28例好转，2例无效；重度患儿6例痊愈，5例好转，1例无效。治疗以痊愈和好转患儿最多。结论婴幼儿肝功能异常的主要病因有感染、药(毒)物损害、遗传代谢病等，应重视肝功，及早进行检查治疗可以减少对患儿的危害，恢复更好。“,”Objective To investigate the etiology,clinical manifestations in children with liver function abnormality and the curative effect of different abnormalities. Methods Clinical data of 120 children with liver function abnormality were reviewed retrospectively. Result Many pathogenic reasons can cause children abnormal liver function, including bacterial infection (42 cases), mycoplasma infection (16 cases), Kawasaki disease(8 cases), medicine (poison) damage(8 cases). medicine (poison) including tetramine, poisonous mushroom, chinese herbal, ceftriaxone, and valproic acid, et al are among the causes. The curative results for mild abnormal liver function were cured(23cases), improved(16cases)and no effect(1case). The curative results for moderate abnormal liver function were cured(38cases), improved(28cases) and no effect(2cases). The curative results for severe abnormal liver function were cured(6cases), improved(5cases)and no effect(1case). Cured and improved curative results were common. Conclusions The major pathogenic causes are caused by infection, druge(poison) damage and congenital metabolic diseases, et al. Clinical manifestations including vomiting, diarrhea, less nausea, anorexia, ascites and jaundice were not appeared among the children. We should pay attention to routine liver function tests,discover and cure the liver function abnormality as early as possible.