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采用受精卵原核显微注射的方法，成功获得稳定整合乙肝病毒基因组DNA的转基因小鼠。经PCR、Dot－blotting或Southern－blotting等方法检测确认后的阳性鼠通过近交或回交的方式现已繁育到第7代，有望育成乙肝病毒转基因小鼠品系。
Transgenic mice stably integrating hepatitis B virus genomic DNA were successfully obtained by pronuclear microinjection of zygotes. The positive mice confirmed by PCR, Dot-blotting or Southern-blotting methods have been bred to the 7th generation by inbred or backcrossing method, which is expected to develop a strain of transgenic mice with hepatitis B virus.