采用表面增强喇曼光谱（ＳＥＲＳ）技术获得了异喹啉及其衍生物（３－羧基异喹啉、１－羧基异喹啉、甲基－３－异喹啉羧酸酯、１－羟基异喹啉、５－羟基异喹啉、１，５－二羟基异喹啉）的ＳＥＲＳ谱图，谱带分析表明由于异喹啉环上取代基不同、取代位置不同，均可导致其ＳＥＲＳ光谱的变化。其中１－羟基异喹啉、甲基－３－异喹啉羧酸酯、３－羧基异喹啉、异喹啉是垂直吸附于银胶表面。而１，５－二羟基异喹啉与５－羟基异喹啉则是通过环上π电子云平躺吸附于银胶表面。 Isoquinolines and their derivatives (3-carboxyisoquinoline, 1-carboxyisoquinoline, methyl-3-isoquinolinecarboxylate, 1-hydroxyisobutyronitrile) were obtained by surface enhanced Raman spectroscopy (SERS) Quinoline, 5-hydroxyisoquinoline and 1,5-dihydroxyisoquinoline). The results of spectral analysis showed that due to the different substituents on the isoquinoline ring and the substitution positions, all the SERS spectra of Variety. Among them, 1-hydroxyisoquinoline, methyl-3-isoquinoline carboxylate, 3-carboxyisoquinoline and isoquinoline are adsorbed vertically on the surface of silver colloids. However, 1,5-dihydroxyisoquinoline and 5-hydroxyisoquinoline adsorbed on the surface of silver colloids by the π electron cloud in the ring.