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目的探讨白介素11联合地塞米松治疗急性放射性口腔炎的临床疗效。方法选取2013—2014年铜仁市人民医院收治的放射性口腔炎患者88例,随机分为对照组和观察组,各44例。对照组给予常规治疗,观察组给予地塞米松联合白介素11治疗,比较两组患者溃疡愈合疗效、疼痛缓解疗效及不良反应发生情况。结果观察组患者的溃疡愈合总有效率高于对照组,差异有统计学意义(P<0.05)。观察组疼痛评分量表(NRS)评分下降幅度大于对照组,疼痛缓解总有效率高于对照组,差异有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论白介素11联合地塞米松治疗急性放射性口腔炎的临床疗效确切,能有效促进溃疡愈合,减轻疼痛,且不良反应少。
Objective To investigate the clinical efficacy of interleukin-11 combined with dexamethasone in the treatment of acute radiation stomatitis. Methods 88 cases of radiation stomatitis admitted in Tongren People’s Hospital from 2013 to 2014 were randomly divided into control group and observation group, 44 cases in each group. The control group was given routine treatment. The observation group was treated with dexamethasone and interleukin-11. The ulcer healing, pain relief and adverse reactions in both groups were compared. Results The total effective rate of ulcer healing in observation group was higher than that in control group, the difference was statistically significant (P <0.05). The decrease of NRS score in observation group was larger than that of control group, and the total effective rate of pain relief was higher than that of control group (P <0.05). Two groups of patients with adverse reactions, the difference was not statistically significant (P> 0.05). Conclusion Interleukin 11 combined with dexamethasone is effective in the treatment of acute radiation stomatitis. It can effectively promote the healing of ulcer and relieve the pain with less adverse reactions.