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目的:观察联合应用辛伐他汀和叶酸片对血脂正常H型高血压患者进行治疗时对颈动脉硬化产生的影响。方法:选择2014年3月至2015年6月在本院接受治疗的78例血脂正常H型高血压患者,随机平分为对照组和观察组。对照组患者给予氨氯地平+辛伐他汀进行治疗,观察组患者在对照组的治疗基础上加用叶酸片进行治疗,对比两组患者颈动脉硬化改善情况。结果:观察组患者颈动脉内膜中层厚度(IMT)及斑块面积均有明显降低,与治疗前和对照组比较,差异具有统计学意义(P<0.05)。结论:叶酸片联合辛伐他汀对血脂正常H型高血压患者进行治疗,可促进患者的颈动脉硬化得到更好改善。
OBJECTIVE: To observe the effect of simvastatin and folic acid tablets on carotid artery atherosclerosis in patients with lipid-normal Hypertension. Methods: From March 2014 to June 2015, 78 patients with Hypertensive Hypertension who were treated in our hospital were randomly divided into control group and observation group. Patients in the control group were treated with amlodipine + simvastatin. Patients in the observation group were treated with folic acid tablets on the basis of the control group, and the carotid atherosclerosis was compared between the two groups. Results: The intima-media thickness (IMT) and plaque area of the carotid arteries in the observation group were significantly lower than those before treatment and in the control group (P <0.05). CONCLUSION: Folic acid tablets combined with simvastatin can improve carotid atherosclerosis in patients with lipid-normal H-type hypertension.