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目的观察丙酸氟替卡松联合沙丁胺醇雾化吸入治疗小儿喘息性肺炎的临床疗效。方法选取2013年5月—2015年4月凉山彝族自治州第二人民医院收治的喘息性肺炎患儿137例,随机分为对照组69例和观察组68例。对照组患儿采用常规治疗,观察组患儿在常规治疗基础上加用丙酸氟替卡松联合沙丁胺醇雾化吸入治疗,比较两组患儿临床疗效、症状或体征改善时间及住院时间、治疗前后肺功能指标,观察治疗期间不良反应发生情况。结果观察组患儿临床疗效优于对照组(P<0.05)。观察组患儿咳嗽、喘息、湿啰音、哮鸣音消失时间及住院时间均短于对照组(P<0.05)。治疗前两组患儿肺活量(VC)、第1秒用力呼气容积/用力肺活量(FEV1/FVC)、最大通气量(MBC)比较,差异无统计学意义(P>0.05);治疗后观察组患儿VC、FEV1/FVC、MBC高于对照组(P<0.05)。观察组患儿不良反应发生率低于对照组(P<0.05)。结论丙酸氟替卡松联合沙丁胺醇雾化吸入治疗小儿喘息性肺炎的临床疗效确切,有利于改善患儿临床症状或体征及肺功能,且不良反应较少。
Objective To observe the clinical efficacy of fluticasone propionate combined with salbutamol inhalation in children with asthmatic pneumonia. Methods A total of 137 children with asthmatic pneumonia admitted to the Second People’s Hospital of Liangshan Yi Autonomous Prefecture from May 2013 to April 2015 were randomly divided into control group (n = 69) and observation group (n = 68). The control group of children with conventional treatment, the observation group of children on the basis of conventional treatment with fluticasone propionate plus salbutamol inhalation therapy, the two groups of children with clinical efficacy, symptoms or signs of improvement and hospitalization time, before and after treatment of lung function Indicators to observe the incidence of adverse reactions during treatment. Results The clinical efficacy of observation group was better than that of control group (P <0.05). The observation group had shorter cough, wheezing, wet rales, disappearance of wheeze and hospital stay than those in the control group (P <0.05). Before treatment, there was no significant difference in vital capacity (VC), first second forced expiratory volume / forced vital capacity (FEV1 / FVC) and maximum ventilation (MBC) between the two groups (P> 0.05) Children with VC, FEV1 / FVC, MBC higher than the control group (P <0.05). The incidence of adverse reactions in observation group was lower than that in control group (P <0.05). Conclusion Fluticasone propionate combined with salbutamol nebulization treatment of children with asthmatic pneumonia clinical curative effect is exact, will help to improve children’s clinical symptoms or signs and lung function, and fewer adverse reactions.