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为了弄清染色体畸变与白血病发病间可能存在的关系,用G和Q分带方法研究了染色体断裂点的分布。取22例距爆心1公里以内的健康原子弹幸存者的外周血,用PHA在37℃培养48小时,观察在1616个细胞中,稳定性染色体型畸变有433个细胞(占26.8%)。用作进一步分析的290个细胞中,共有592个断裂点。其结果如下:(1)某些染色体臂上的断裂点的实际数比顶期数要高。(2)根据区的长度,断裂点的高发区为22q1,5q3,4q3,6q2,14q3,21q2,13q3,围绕着丝点区为低发区为4~*,11~*,9~*和17~*。(3)在原子弹幸存者的染色体断裂点高发区与淋巴性白血病细胞14q~+,6q~-,22q~-区,粒细胞性白血病细胞22q~-,5q~-
In order to find out the possible relationship between chromosomal aberrations and leukemia incidence, the distribution of chromosome breakpoints was studied by G and Q zoning methods. Peripheral blood from 22 healthy nuclear survivors within 1 kilometer of the blast core was collected and cultured with PHA at 37 ° C for 48 hours. In 1616 cells, there were 433 cells (26.8%) with stable chromosomal aberrations. Of the 290 cells used for further analysis, there were 592 breakpoints. The results are as follows: (1) The actual number of breakpoints on some chromosome arms is higher than the number of tops. (2) According to the length of the district, the high incidence area of break point is 22q1, 5q3, 4q3, 6q2, 14q3, 21q2 and 13q3, and 4 ~ *, 11 ~ *, 9 ~ * and 17 ~ *. (3) In the areas of 14q ~ +, 6q ~ -, 22q ~ - of lymphocytic leukemia cells and 22q ~ -, 5q ~ -