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Three new C-3 dehydrated bufadienolides were isolated from the venom of Bufo bufo gargarizans. Their structures were elucidated as 5b,12b-12,14-dihydroxy-11-oxobufa-3,20,22-trienolide(1), 5b,12b-12,14-dihydroxy-11-oxobufa-2,20,22-trienolide(2), and 5b,12a-12,14-dihydroxy-11-oxobufa-2,20,22-trienolide(3) on the basis of extensive spectroscopic analysis, especially 1D NMR and 2D NMR data. In addition, all three compounds were tested for their cytotoxic activities against A549 and HepG2 cancer cell lines. Compounds 2 and 3 showed significant cytotoxicities with IC50 values less than 10 mmol/L on both cancer cells.
Three new C-3 dehydrated bufadienolides were isolated from the venom of Bufo bufo gargarizans. Their structures were elucidated as 5b, 12b-12,14-dihydroxy-11-oxobufa-3,20,22- trienolide (1) -12,14-dihydroxy-11-oxobufa-2,20,22-trienolide (2), and 5b, 12a- of extensive spectroscopic analysis, especially 1 D NMR and 2D NMR data. In addition, all three compounds were tested for their cytotoxic activities against A549 and HepG2 cancer cell lines. 2 and 3 showed significant cytotoxicities with IC50 values less than 10 mmol / L on both cancer cells.