复发性阿弗他溃疡(RAU)是病因不明的最常见的口腔黏膜溃疡类疾病。近年来对重型或发作频繁、症状严重的RAU患者,以沙利度胺作为全身用药的疗效已得到多方验证,但给药方式、初始剂量与维持剂量以及疗程等远未达成共识,本文就沙利度胺在RAU治疗中的方案优选和规范化研究进展进行综述。 Recurrent aphthous ulcer (RAU) is the most common cause of unexplained oral mucosal ulcer disease. In recent years, heavy or frequent episodes of RAU patients with severe symptoms, the efficacy of thalidomide as a systemic drug has been multi-party verification, but the mode of administration, the initial dose and maintenance dose and treatment is far from reaching a consensus, this article on the sand The review of regimen optimization and standardization in the treatment of RAU is reviewed.