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给小鼠灌胃~３Ｈ－甘露聚糖（ＳＰ＿１）后，３０ｍｉｎ即可从血液中测到放射性，６０ｍｉｎ血中放射性达高峰；于不同时间对各组织放射性的定量测定及小鼠整体切片的放射自显影结果均证明，~３Ｈ－甘露聚糖经口服可被机体吸收。进入小鼠体内的放射性物质主要从粪与尿中排泄，从胆汁排泄较少，给药后４８ｈ区间内，从粪、尿、胆汁中累积排出的，总放射性分别占给药剂量的４２％、２９％、５．４％。经Ｓｅｐｈａｒｏｓｅ－ＤＬ－４Ｂ柱层析鉴定，经口服吸收入血的ＳＰ＿１分子量不变。给药后１ｈ，血清中的ＳＰ＿１约占给药剂量的１１％。经纸层析对代谢物鉴定，粪中有２２％为原型药物，尿中未检出原型药。
Radioimmunoassay was performed 30 min after radioimmunoassay to ~ 3H-mannan (SP_1) in mice. The radioactivity peaked at 60 min. The radioactivity of each tissue was measured at different times and the radioactivity of whole mouse slices Self-imaging results have shown that ~ 3H-mannan by oral absorption by the body. Radioactive materials entering the body of the mice mainly excreted in excrement and urine and excreted less from the bile. After 48h administration, cumulative radioactivity accumulated in excrement, urine and bile in the mice accounted for 42% of the total dose, 29%, 5.4%. Identified by Sepharose-DL-4B column chromatography, the molecular mass of SP_1 absorbed into the blood by oral administration was unchanged. At 1 h after administration, serum SP_1 accounted for about 11% of the dose. Metabolite identification by paper chromatography, stool in 22% of the prototype drugs, urine samples were not detected.