论文部分内容阅读
目的:探讨上海等地区丙型肝炎患者中 HCV 基因型的分布。方法:以一种新的 HCV 基因分型方法——线探针试验(INNO-LiPA),对来源于上海等地区的96例慢性丙型肝炎患者进行 HCV 基因分型。结果:显示96例患者中以1b 型为主(占77.6%),其次为2a/2c(占8.62%),并发现1a、4a 和4e 基因亚型。82例感染单一型(1b),其他14例为混合感染,有一例慢性丙型肝炎患者感染5个亚型。对其中39例病人应用干扰素(IFN-a)治疗,37.5%感染1b 亚型的患者在治疗期间 HCV-RNA 由阳性转为阴性,而57.1%感染其他型的患者在治疗期间 HCV-RNA 由阳性转为阴性。结论:分型方法操作简便,可作为预测丙型肝炎患者抗病毒治疗疗效方法之一。
Objective: To investigate the distribution of HCV genotypes in patients with hepatitis C in Shanghai and other areas. Methods: HCV genotyping was performed on 96 chronic hepatitis C patients from Shanghai and other regions by INNO-LiPA, a new HCV genotyping method. Results: Of the 96 patients, 1b was predominant (77.6%) followed by 2a / 2c (8.62%) and the 1a, 4a and 4e genotypes were found. 82 cases infected with a single type (1b), the other 14 cases were mixed infection, one case of chronic hepatitis C infection in five subtypes. Of the 39 patients treated with interferon (IFN-a), 37.5% of patients with subtype 1b infection turned negative from positive to HCV-RNA while 57.1% of other patients infected during the course of treatment were treated with Positive to negative. Conclusion: The typing method is simple and convenient and can be used as one of the methods to predict the antiviral effect of hepatitis C patients.