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20世纪50年代,在伊朗发现了这样的怪病患者:20岁左右,男性,身材矮小,智力低下,没出现性发育,严重贫血,皮肤粗糙,有些患者还喜欢吃泥土。由于患者有严重贫血症,开始医生以为是缺铁造成的,给患者补充铁剂后,贫血症状略有改善,但其他症状却毫无减轻。后来研究发现,这些患者的病症与动物实验中小白鼠缺锌的症状相似,于是就让患者口服锌制剂,发现补锌后他们的生长速度明显加快,用药3个月内全部出现了性发育。这是人类首次发现
In the 1950s, a strange patient was found in Iran: about 20 years old, males, short stature, mental retardation, no sexual development, severe anemia, rough skin, and some patients also like to eat soil. As the patient had severe anemia, the doctor thought it was caused by iron deficiency. After adding iron to patients, the symptoms of anemia improved slightly, but no other symptoms were relieved. Later, the study found that the symptoms of these patients with animals and zinc deficiency in mice similar symptoms, so let patients oral zinc preparations found zinc significantly faster growth rate of their medication within 3 months after all the sexual development. This is the first human discovery