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本文对５例阵发性睡眠性血红蛋白尿症（ＰＮＨ）的红细胞形态在扫描电镜下进行了观察，结果表明ＰＮＨ患者红细胞中光滑盘形明显减少，仅占５８．９％±９．１％，与正常对照（９３．０±２．６４％）相比，Ｐ＜０．００１，异常形态红细胞明显增多，其中环形红细胞高达２５±１０．７％（Ｐ＜０．００１），单嵴盘形、球口形、盆盘形及陷窝形红细胞均增多。经１ｔμｇ／ｍｌ亚硒钠孵育４小时后，光滑盘形红细胞稍增加（６６．７±４．３２％，与孵育前比Ｐ＞０．０５），环形及其他异常形态红细胞亦有所减少。我们过去工作曾证实微量元素硒具有保护ＰＮＨ患者红细胞膜减轻过氧化损伤、促进酶活性减轻溶血的作用，本研究表明加硒后在扫描电镜下红细胞的形态异常也有一定程度的改善，但尚不够显著。
In this paper, 5 cases of paroxysmal nocturnal hemoglobinuria (PNH) erythrocyte morphology was observed under a scanning electron microscope, the results show that PNH patients erythrocyte smooth disc significantly decreased, accounting for only 58.9% ± 9.1% Compared with the normal control (93.0 ± 2.64%), the abnormal erythrocytes increased significantly (P <0.001), the erythrocytes were as high as 25 ± 10.7% (P <0.001) , Ball-shaped, basin-shaped and lacunar erythrocytes were increased. After 4 hours’ incubation with 1tμg / ml sodium selenite, smooth disk erythrocytes slightly increased (66.7 ± 4.32%, compared with pre-incubation P> 0.05), and the number of annular and other abnormal erythrocytes also decreased. Our past work has confirmed that trace element selenium has protective effect of erythrocyte membrane in patients with PNH to reduce peroxidation damage and promote enzyme activity to reduce hemolysis, the study showed that after selenium in scanning electron microscopy erythrocytes morphological abnormalities have improved to some extent, but not enough Significant.