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通过在DNA组装的纳米金棒上实现金的再生长,我们合成了一种哑铃状的复合金纳米结构。通过紫外-可见吸收发现,该结构在较小的尺寸下,表现出良好的近红外吸收特性,这为进行深层组织光热治疗提供了一种良好的载体。另外,通过改变还原剂与氯金酸的比率及还原剂的种类,可以得到金棒两端生长“刺状突起”和“海胆状”金纳米结构。由于这两种结构具有较大的比表面使其在表面增强拉曼和金属催化等方面具有潜在的应用;同时该结构可用于包裹标记同位素作为放射性药物进入细胞或体内的载体。
By re-growing gold on a nano-gold rod assembled with DNA, we synthesized a dumbbell-like composite gold nanostructure. It was found by ultraviolet-visible absorption that the structure showed good near-infrared absorption characteristics under the small size, which provided a good carrier for photothermal therapy of deep tissues. In addition, by changing the ratio of reductant to chloroauric acid and the type of reductant, both ends of the gold rod can grow “spiny” and “sea urchin” gold nanostructures. Due to their large specific surface area, these two structures have potential applications in surface-enhanced Raman and metal catalysis. At the same time, the structure can be used as a carrier for radiolabeling labeled radioisotope into cells or in vivo.