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目的探讨新生儿低血糖性脑损伤的危险因素及预后。方法选择我院2008年6月至2011年6月的新生儿低血糖有脑损伤的病例20例作为病例组,并随机选择同期住院的新生儿低血糖无脑损伤的病例25例作为对照组。对两组患儿的临床资料进行回顾性分析。结果两组患儿平均胎龄、出生平均体质量及首次诊断低血糖时间无显著性差异(P>0.05);病例组平均最低血糖值低于对照组(P<0.01),低血糖持续时间长于对照组(P<0.01)。病例组19例患儿进行6～18个月随访,发生低血糖脑损伤神经系统后遗症12例(63.16%),对照组无神经系统后遗症。结论新生儿血糖值越低,脑损伤越重;低血糖持续时间越久,脑损伤越重;低血糖脑损伤预后差,神经系统后遗症发生率高。
Objective To investigate the risk factors and prognosis of neonatal hypoglycemic brain injury. Methods 20 cases of neonatal hypoglycemia with brain injury in our hospital from June 2008 to June 2011 were selected as the case group and 25 cases of neonatal hypoglycemia without brain injury at the same period were randomly selected as the control group. The clinical data of two groups were retrospectively analyzed. Results The average gestational age, birth weight and the time of the first diagnosis of hypoglycemia were not significantly different between the two groups (P> 0.05). The mean minimum blood glucose of the patients was lower than that of the control group (P <0.01), the duration of hypoglycemia was longer than Control group (P <0.01). Nineteen children in the case group were followed up for 6 to 18 months. There were 12 cases (63.16%) with sequelae of hypoglycemic brain injury and no neurological sequelae in the control group. Conclusion The lower the neonatal blood glucose, the heavier the brain injury. The longer the duration of hypoglycemia, the more severe brain injury. The poor prognosis of hypoglycemic brain injury and the high incidence of nervous system sequelae.