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双磷酸盐类药物在多发性骨髓瘤(multiple myeloma,MM)中的支持治疗作用已经得到肯定,近年来双磷酸盐通过激活γδT细胞在MM中的免疫调节作用及抗MM的作用越来越受到重视,本文就双磷酸盐在MM治疗中的免疫调节作用及抗肿瘤效应的机制、临床应用作一综述。
The supportive therapeutic effect of bisphosphonates in multiple myeloma (MM) has been affirmed. In recent years, bisphosphonates have been increasingly affected by the immunomodulatory effects of γδT cells in MM and the anti-MM effect Attention, this article bisphosphonate in MM treatment of immunomodulatory effects and anti-tumor effect of the mechanism of clinical application as a review.