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目前生产当归注射液主要有蒸馏法、煎煮法及醇提法。《江西省药品标准》(1982)版(以下简称“标准”)采用的就是醇提法,但在制备过程中,原料的新鲜与陈旧对含量影响较大,现将试验结果总给报告如下:一、方法:取不同产地的新鲜原料和当地医药部门存放较久的当归原料,每隔一个季度按“标准”当归注射液项下的制备方法制备。二、含量测定:按“标准”当归注射液项下的含量测定方法进行测定,结果见右表。三、分析与讨论:1.由于当归成分复杂,在无法对有效成分更为具体的分析鉴定的情况下,“标准”对当归注射液中的含量测定,采用控制当归中还原性成分的含量测定方法是可行的,本法对当归原料的质量好坏是较为有效的控制方法。因为当归中含大量挥发性内酯成分如藁本内脂,丁烯基苯酞等。有的易氧化变质。
The current production of Angelica injection mainly includes distillation, decoction and alcohol extraction. The “Jiangxi Province Drug Standards” (1982) edition (hereinafter referred to as “the standard”) adopts the alcohol extraction method. However, in the preparation process, the freshness and oldness of the raw materials have a great influence on the content. The test results are now reported as follows: I. Method: Fresh raw materials from different producing areas and local medicine department store long-term raw materials of Angelica sinensis, and prepare them according to the preparation method under “standard” Angelica injection items every other quarter. Second, the content determination: According to the “standard” Angelica injection content determination method, the results shown in the right table. III. Analysis and discussion: 1. Due to the complex composition of Angelica sinensis, in the absence of more specific analysis and identification of active ingredients, the “standard” determination of the content of Angelica Sinensis Injection is based on the determination of the content of reducing ingredients in Angelica sinensis. The method is feasible. This method is a more effective control method for the quality of Chinese angelica raw materials. Because Angelica contains a large number of volatile lactone components such as ligustic lactone, butenyl benzoquinone and so on. Some are easily oxidized.