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目的:研究新型仙灵骨葆胶囊中淫羊藿有效成分朝藿定C和淫羊藿苷的大鼠肠吸收特性,并与仙灵骨葆胶囊肠吸收结果进行对比。方法:采用大鼠离体非翻转肠囊法,以HPLC对朝藿定C和淫羊藿苷进行检测,研究吸收部位和药物浓度对朝藿定C和淫羊藿苷肠吸收的影响。结果:朝藿定C在十二指肠的吸收优于空肠和回肠,且有统计学意义(P<0.05);淫羊藿苷在空肠的吸收低于十二指肠和回肠,且有统计学意义(P<0.05)。高、中、低3个浓度胶囊内容物中朝藿定C和淫羊藿苷的Ka无显著性差异,朝藿定C高、中、低3个浓度的Ka分别为0.0400,.058,0.061 h-1,淫羊藿苷高、中、低3个浓度的Ka分别为0.002,0.0070,.003 h-1。结论:朝藿定C和淫羊藿苷的肠吸收不受浓度影响。新工艺仙灵骨葆胶囊中朝藿定C和淫羊藿苷的肠吸收均好于旧工艺。
OBJECTIVE: To study the intestinal absorption characteristics of Epimedium C and icariin in XinXianGuBao Capsules, and to compare the intestinal absorption with xingling gubao capsules. Methods: In vitro non-reversing enteric sac method was used to detect epimedin C and icariin to study the effect of absorption site and drug concentration on the absorption of epimedin C and icariin. RESULTS: The absorption of epimedin C in the duodenum was superior to that in the jejunum and ileum (P <0.05). The absorption of icariin in jejunum was lower than that in the duodenum and ileum Significance (P <0.05). High, medium and low concentrations of capsule content of Epimedin C and Icariin Ka no significant difference, Epimedin C high, medium and low concentrations of three Ka were 0.0400, .058,0.061 h-1, icariin high, medium and low concentrations of Ka were 0.002,0.0070, .003 h-1. CONCLUSION: The intestinal absorption of Epimedin C and icariin was independent of concentration. The new process Xianling Gubao Capsules Epimedin C and Icariin intestinal absorption were better than the old process.