目的探讨孕晚期米索前列醇促宫颈成熟治疗的疗效及不良反应。方法孕妇222例,其中110例为观察组,采用米索前列醇25μg置于阴道后穹隆,每6小时1次促宫颈成熟。112例为对照组,采用缩宫素2 U+500 ml生理盐水静脉滴注促宫颈成熟。对比两组临床疗效。结果观察组有效率80.9%,阴道分娩率72.7%;对照组有效率61.6%,阴道分娩率51.8%,两组比较差异有统计学意义(P<0.05)。结论米索前列醇在严格掌握指征后用于促宫颈成熟治疗安全,有效,经济,能有效降低剖宫产率。 Objective To investigate the curative effect and adverse reactions of misoprostol for cervical ripening in late third trimester of pregnancy. Methods 222 pregnant women, of which 110 cases were treated with misoprostol 25μg placed in the vaginal vault, urinary cervix matured once every 6 hours. 112 cases as control group, the use of oxytocin 2 U + 500 ml saline intravenous infusion of cervical ripening. Compare two groups clinical curative effect. Results The observation group had an effective rate of 80.9% and a vaginal delivery rate of 72.7%. The effective rate of the control group was 61.6% and the vaginal delivery rate was 51.8%. There was significant difference between the two groups (P <0.05). Conclusion Misoprostol is a safe, effective and economical method for cervical ripening after strict indications. It can effectively reduce the rate of cesarean section.