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目的探讨山黧豆ＬａｔｈｙｒｕｓＳａｔｉｖｕｓ中毒引起的运动神经元损害，以防止山黧豆对人体健康的损害。方法我们确定了山黧豆中毒的诊断标准：①有吃山黧豆的历史；②有中毒症状；③有锥体束征；④排除神经系统其他疾病。只有前２条标准，不诊断为山黧豆中毒，列为可疑病例。普查了２１２８名农民，并作了神经系统检查，确诊了山黧豆中毒病人，并进行治疗。结果我们所普查的２１２８名农民中发现１１９例中毒病人，占总普查人数的５．６％，其中男性９５例，女性２４例，主要的中毒症状和体征是：双侧下肢痉挛性无力，膝反射、跟踺反射亢进，有持续性或不持续踝阵挛，大多数病人有病理反射，少数病人有小腿肌肉萎缩。结论山黧豆中毒引起的运动神经元损害与过量进食山黧豆有关。山黧豆中含有β－草酰氨基丙氨酸等，结果表明每日食用兴奋性氨基酸，造成了氨基酸的代谢紊乱，这些兴奋性氨基酸引起兴奋性损害，主要为运动神经元变性，对山黧豆中毒的部分病人随访３～２３年无１例完全恢复。
Objective To investigate the damage of motor neuron caused by LathyrusSativus poisoning in mountain shrimp to prevent the harm of mountain shrimp to human health. Methods We identified the diagnostic criteria for mountain bean poisoning: ① history of eating mountain beans; ② symptoms of poisoning; ③ pyramidal tract signs; ④ exclude other diseases of the nervous system. Only the first two criteria, not diagnosed as mountain bean poisoning, as suspicious cases. A total of 2,128 farmers were surveyed and neurological examinations were performed. Patients suffering from mountain bean poisoning were diagnosed and treated. Results Of the 2128 farmers we surveyed, 119 cases of poisoning were found, accounting for 5.6% of the total number of censuses, including 95 males and 24 females. The main symptoms and signs of poisoning were: spastic weakness of both lower extremities, knee Reflex, with 踺 hyperreflexia, persistent or non-persistent ankle clonches, most patients have pathological reflex, a small number of patients have calf muscle atrophy. Conclusions Motor neuron damage caused by mountain bean poisoning is related to excessive consumption of mountain bean. Shanbei beans contain β-oxaloaminoalanine, etc., the results show that the daily consumption of excitatory amino acids, resulting in metabolic disorders of amino acids, these excitatory amino acids cause excitotoxic damage, mainly motor neuron degeneration, Yamane Some patients with bean poisoning were followed up for 3 to 23 years without 1 case of complete recovery.