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用５８只昆明雌鼠，于围产期（孕第１５ｄ至胎鼠出生后１５ｄ）给雌鼠灌服雷藤氯内酯醇（Ｔ＿４）（０．６ｍｇ／ｋｇ／ｄ及０．３ｍｇ／ｋｇ／ｄ），观察了子１代及子２代鼠的出生、生长、发育以及生殖能力。运用行为测试指标测定Ｔ４是否引起后代畸形；采用形态学方法检查胎鼠脏器及骨骼，以判断人是否具有毒性作用及导致畸形。结果表明，子１代及子２代鼠的生长、发育以及生殖能力正常，器官发育正常，运动反射属正常范围；内脏器官未见中毒性病变；胎鼠骨骼发育正常。
Fifty - five female Kunming mice were given telmisalpin alcohol (T_4) (0.6 mg / kg / d and 0.3 mg / kg) during the perinatal period (15 days after pregnancy to 15 days after birth) / D), the birth, growth, development and reproductive capacity of the first generation and second generation of mice were observed. The use of behavioral testing indicators to determine whether T4 causes offspring deformity; Morphological methods to check the internal organs and bones of the fetus to determine whether the human toxicity and lead to deformity. The results showed that the first generation and second generation of mice had normal growth, development and reproductive ability, normal organ development, normal motor reflex range, no toxic lesions in internal organs and normal fetal bone development.