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目的仿真研究心血管系统对下体负压（ＬＢＮＰ）的反应。方法建立了一个数学模型，模型包括７部分：血液重分配控制、左室灌注、左室、外周循环、心率调节控制、外周阻力调节控制、静脉紧张程度控制。其中，心率和静脉紧张度受动脉压力感受器反射控制，而外周阻力则同时受动脉压力感受器和心肺压力感受器的反射控制。结果利用所建模型，模拟了０～－１０．６４ｋＰａ（－８０ｍｍＨｇ）范围内ＬＢＮＰ暴露时心血管系统的反应，模拟ＬＢＮＰ暴露时收缩压、平均压、心率和心输出量的变化以及血压反应过程，仿真结果均与人体实验结果吻合。结论所建模型是有效的，可以模拟ＬＢＮＰ下血液动力学的短期反应。
Objective To simulate the cardiovascular response to lower body negative pressure (LBNP). Methods A mathematical model was established. The model consisted of seven parts: blood redistribution control, left ventricular perfusion, left ventricular and peripheral circulation, control of heart rate, regulation of peripheral resistance and control of venous tension. Among them, heart rate and venous tension are controlled by the arterial baroreceptors, while peripheral resistance is controlled by the reflex of the arterial baroreceptors and cardiorespiratory nociceptors. Results The model was used to simulate the cardiovascular response during exposure to LBNP in the range of 0 ~ -10.64 kPa (-80 mmHg), and to simulate the changes of systolic blood pressure, mean pressure, heart rate and cardiac output during LBNP exposure, , The simulation results are consistent with the results of human experiments. Conclusion The model is valid and can simulate the short-term hemodynamic response to LBNP.