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用患有进展期Ｓ１８０肉瘤的小鼠进行的重复实验证实，绞股蓝总皂甙（ＧＰ）对Ｓ１８０肉瘤有明显的抑制作用，使肿瘤生长延缓，肿瘤坏死比率（肿瘤坏死面积ＴＮＡ／肿瘤总面积ＴＴＡ×１００％）显著增加，瘤周瘤内淋巴细胞、巨噬细胞浸润明显增多，荷瘤鼠脾重明显增加，脾白髓动脉周围淋巴鞘显著增大。阿霉素（ＡＤＭ）或５－氟尿嘧啶（５－Ｆｕ）与ＧＰ联用后，上述各指标均明显优于其分别单用，且ＧＰ能明显减轻阿霉素、５－氟尿嘧啶对骨髓的抑制作用。
Repeat experiments using mice with advanced S180 sarcoma confirmed that Gypenosides (GP) significantly inhibited S180 sarcoma, delayed tumor growth, and tumor necrosis rate (tumor necrosis area TNA/total tumor area TTA × 100%) significantly increased, lymphoma, macrophage infiltration in the tumor area increased significantly, the spleen weight of the tumor-bearing mice increased significantly, and the lymphatic sheath around the splenic white marrow artery significantly increased. After the combination of adriamycin (ADM) or 5-fluorouracil (5-Fu) and GP, the above indicators were all significantly better than their respective single use, and GP can significantly reduce the inhibition of adriamycin and 5-fluorouracil on bone marrow. .