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以体外试验方法替代动物体内试验进行新药及各种健康相关产品的安全性评价可以减少动物用量 ,降低实验成本 ,提高检测效能。用于确认化学物质致癌性的长期动物致癌试验因需数百只啮齿类动物终身染毒和观察而成为安全性评价实验中成本最高、耗时最长的困难试验 ,亟需研究寻找有?
In vitro tests to replace animals in vivo tests for new drugs and various health-related safety evaluation of products can reduce the amount of animals, reduce experimental costs, improve test performance. Long-term animal carcinogenicity test to confirm the carcinogenicity of chemical substances is the most costly and time-consuming difficult experiment in safety evaluation due to lifetime exposure and observation of hundreds of rodents.