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1986年我们进行维甲酸气雾成膜剂的研制及其治疗皮肤病效果观察,在先行涂膜剂型制备并试用于临床,以观察效果和确定适宜治疗浓度时,发现对扁平疣疗效显著,特报告如下。处方设计与给药方法处方:全反式维甲酸(东北制药总厂产品)0.1,非那根0.1,麝香草酚0.2,成膜基质(聚醋乙烯酯15.0,醋酸甲酯45.0及适量有机溶媒和防腐剂)加至100.0。用法:用玻棒或手指蘸取药液,均匀涂于患处。每日2～3次。每次涂药前须除去上次涂药后所形成的药膜。对照组采用去炎松霜,每日2～3次。
In 1986, we developed the retinoic acid aerosol film-forming agent and its effect on the treatment of dermatosis. In the first case, the preparation and trial application of the film-coated dosage form were made in clinic. In order to observe the effect and determine the appropriate therapeutic concentration, The report is as follows. Prescription design and administration prescription: All-trans retinoic acid (Northeast Pharmaceutical Factory) 0.1, phenanthrene 0.1, thymol 0.2, film-forming matrix (vinyl acetate 15.0, methyl acetate 45.0 and the amount of organic solvent And preservative) to 100.0. Usage: Use glass rods or fingers dipped in liquid, evenly applied to the affected area. 2 to 3 times a day. Before each application to be removed before the last drug coating formed. The control group used anti-inflammatory cream, 2 to 3 times daily.