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氯氮平(clozapine)是一种新型抗精神病药物,属二苯并二氮杂(?)类。1986年应用于精神科临床。本药具有奏效快、疗效高、副作用小的特点,尤以较少产生锥体外系反应为其优点。对急、慢性精神分裂症、躁狂症有良好疗效,能较快控制兴奋躁动,不失为抗精神病的一种良药。本药的副作用主要是引起植物神经系统症状,但并不影响治疗的进行。此外可见有流涎、倦怠、乏力、嗜睡、消化道反应、低血压、发热及癫痫发作。个别病例可出现粒细胞减少症或皮疹。现将我院应用国产氯氮平(上海第十九药厂产品)治疗中出现癫痫小发作及皮疹共3例报道如下。
Clozapine (clozapine) is a new antipsychotic drugs, is a benzodiazepine (?) Class. 1986 applied to psychiatric clinical. The drug has a rapid response, high efficacy, side effects of small features, especially in the less extrapyramidal reaction for its advantages. On acute and chronic schizophrenia, mania has a good effect, can quickly control the excitement restlessness, after all, a good medicine for anti-psychosis. The side effects of this drug are mainly caused by autonomic nervous system symptoms, but does not affect the treatment. Also seen salivation, fatigue, fatigue, drowsiness, digestive tract reactions, hypotension, fever and seizures. In some cases there may be neutropenia or rash. Now our hospital application of domestic clozapine (Shanghai No. 19 pharmaceutical products) in the treatment of epileptic seizures and rash were 3 cases reported below.