Ⅰ型胶原是牙周韧带等各种结缔组织的细胞外基质的主要成分。因其在牙移动中起重要作用,许多作者都研究了其改建的机理,但对胶原代谢部位缺乏高度特异性的研究。本研究用非放射性地高辛标记寡脱氧核苷探针,对大鼠磨牙Ⅰ型胶原mRNA作原位杂交,研究牙移动引起牙周韧带改建的形式。 Type I collagen is a periodontal ligament and other connective tissue of the extracellular matrix of the main components. Because of their important role in tooth movement, many authors have studied the mechanism of its remodeling, but lack of highly specific studies on the site of collagen metabolism. In this study, non-radioactive digoxigenin-labeled oligodeoxynucleoside probe for rat molar type Ⅰ collagen mRNA in situ hybridization study of tooth movement caused by periodontal ligament reconstruction of the form.