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目的：观察补肾益心片对肾血管性高血压大鼠血浆过氧化脂质及性激素的影响。方法：建立Ｇｏｌｄｂｌａｔｔ＇ｓ二肾一夹型高血压大鼠模型（Ｇ－２Ｋ１Ｃ），以开搏通为对照药，设立补肾益心片高、中、低剂量组，开搏通组，模型组，假手术组，灌胃４周后测定大鼠尾动脉压，并取血测脂质过氧化物（ＬＰＯ），超氧化物歧化酶（ＳＯＤ），谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ），睾酮（Ｔ）和雌二醇Ｅ ２ 。结果：与模型组比较补肾益心片高、中、低剂量组及开搏通组能降低肾血管性高血压大鼠的血压（Ｐ＜０．０１）；可降低肾血管性高血压大鼠血浆的ＬＰＯ，提高ＳＯＤ和ＧＳＨ－Ｐｘ（Ｐ＜０．０１）；补肾益心片各组可纠正高血压大鼠睾酮和雌二醇的失调。结论：补肾益心片具有确切的降血压作用，可改善高血压大鼠睾酮与雌二醇的失调（Ｐ＜０．０１）。
Objective: To observe the effect of Bushen Yixin Tablet on plasma lipid peroxidation and sex hormones in rats with renovascular hypertension. METHODS: A Goldblatt’s two-kidney and one-clip hypertensive rat model (G-2K1C) was established. With the use of captopril as a reference drug, high-, middle-, and low-dose groups of Bushen Yixin Tablets were established. The captopril group and model group were established. In sham operation group, the tail artery pressure was measured 4 weeks after intragastric administration. The blood was measured for lipid peroxide (LPO), superoxide dismutase (SOD), and glutathione peroxidase (GSH- Px), Testosterone (T) and Estradiol E2. RESULTS: Compared with the model group, the high, middle and low doses of Bushen Yixin Tablets and captopril group can reduce the blood pressure of renovascular hypertensive rats (P<0.01); Plasma LPO increased SOD and GSH-Px (P<0.01); Bushen Yixin Tablets could correct the imbalance of testosterone and estradiol in hypertensive rats. Conclusion: Bushen Yixin Tablet has the effect of reducing blood pressure, which can improve the imbalance of testosterone and estradiol in hypertensive rats (P<0.01).