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选择牙周健康者（Ｈ）及边缘性龈炎（ＭＧ）、慢性成人牙周炎（ＣＡＰ）、快速进展型牙周炎（ＲＰＰ）患者共３５人，２０４颗牙齿，测定其龈沟液（ＧＣＦ）中碱性磷酸酶（ＡＬＰ）的水平。发现牙周组织有破坏的患牙（ＣＡＰ和ＲＰＰ组），其龈沟液（ＧＣＦ）－碱性磷酸酶（ＡＬＰ）水平高于牙周无破坏者（Ｈ和ＭＧ组），ＧＣＦ－ＡＬＰ水平与牙周临床指标呈高度正相关；牙周治疗后临床指标及ＧＣＦ－ＡＬＰ水平均明显下降。提示ＧＣＦ－ＡＬＰ可能是牙周组织炎症状况和破坏程度的一项有意义的诊断指标。
A total of 35 teeth and 204 teeth with periodontal health (G), marginal gingivitis (MG), chronic adult periodontitis (CAP) and rapid progression periodontitis (RPP) were selected and their gingival crevicular fluid GCF) alkaline phosphatase (ALP) levels. (CAP and RPP group), the levels of GCF and ALP in periodontal tissue were higher than those in periodontal non-destructive (H and MG) group. The level of GCF-ALP And periodontal clinical indicators were highly positive correlation; after periodontal treatment clinical indicators and GCF-ALP levels were significantly decreased. It is suggested that GCF-ALP may be a meaningful diagnostic indicator of inflammation and destruction of periodontal tissues.