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本工作试图了解Anordrin 的抗孕作用机理。交配后6天,正常着床的小鼠,选入本实验。实验组分别在交配后第6天、6～7天、6～8天,灌服不同剂量的Anordrin。对照组不灌药。分别在交配后7天、8天、9天,处死两组动物,取全部子宫固定、包埋通过着床点连续切片,光镜观察。结果孕后第6天单次给药,对着床点发育无影响,第6～7天连续2次给药者,部分着床点发生病变;6～8天连续3次给药,则几乎全部着床点发生病变。药物主要损伤绒毛、绒毛膜及胎盘组织。
This work attempts to understand Anordrin mechanism of anti-pregnancy. Six days after mating, normal implantation mice were selected for the experiment. The experimental group were dosed with different doses of Anordrin on the 6th, 6th to 7th, 6th to 8th day after mating respectively. The control group did not fill the drug. Animals were sacrificed at 7 days, 8 days and 9 days after mating, respectively. All the animals were sacrificed and fixed in the uterus. The results of 6 days after pregnancy single administration, no impact on the implantation site development, 6 to 7 days for 2 consecutive administration, some implantation site lesions; 6 to 8 days for 3 consecutive administration, then almost All implantation site lesions. The main drug damage villi, chorion and placental tissue.