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对44例原发性癫痫患儿与健康对照儿童进行IgG、IgA、IgM、补体C_3、循环免疫复合物(CIC)、抗核抗体(ANA)、抗脑抗体(ABAb)、淋巴细胞转化试验刺激指数(SI)、NK细胞活性、IL-2活性等10项免疫指标测定。结果显示,患儿不同程度地存在细胞免疫、体液免疫功能低下及自身抗体阳性,並有43%的患儿检出IgG增高,反映出部分癫痫患儿免疫功能异常。本文认为癫痫患儿特异性自身抗体如抗脑抗体产生是导致脑组织免疫性损伤,引起大脑皮层癫痫样放电而发病的基础。而自身抗体的出现是由于细胞免疫和体液免疫功能低下的结果。
Forty - four children with primary epilepsy and healthy control children were stimulated with IgG, IgA, IgM, complement C_3, circulating immune complex (CIC), antinuclear antibody (ABAb), lymphocyte transformation test Index (SI), NK cell activity, IL-2 activity and other 10 indicators of immune determination. The results showed that children with varying degrees of cellular immunity, humoral immune dysfunction and autoantibodies positive, and 43% of children were detected IgG increased, reflecting the immune function in some children with epilepsy. This article suggests that children with epilepsy-specific autoantibodies such as anti-brain antibodies produce brain damage caused by immunity, causing cerebral cortex epileptiform discharge and the incidence of the foundation. The emergence of autoantibodies is due to cellular and humoral immune dysfunction.