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本文通过阿司匹林(下简称ASP)片体内血药浓度的测定,以探索ASP片在人体及动物体内动力学模型。根据动力学及隔室概念,药物从一个室转移到另一个室的速率常用速度常数来表示,因此,借助速度常数即可计算药理参数。一般口服给药多为二室,亦可能不是二室。关于一室的表达式可由dx/dt=-K_aX_a推导而得 C=(K_a-X_a)/(Vd(K_a-K_e))(e-Ket-e-Kat) (1)
In this paper aspirin (hereinafter referred to as ASP) in vivo plasma concentration determination, in order to explore ASP tablets in the human body and animal kinetic model. Based on the kinetics and compartment concept, the rate at which a drug is transferred from one compartment to another is often expressed as a speed constant, so pharmacokinetic parameters can be calculated using the velocity constants. Oral administration is usually more than two rooms, it may not be two rooms. The expression for a cell can be derived from dx / dt = -K_aX_a C = (K_a-X_a) / (Vd (K_a-K_e)) (e_Ket_e_ Kat) (1)