金黄色葡萄球菌是医院内、外感染最常见的病原体之一,其所致感染病死率高、耐药严重,给治疗带来了极大困难。疫苗是预防金黄色葡萄球菌感染的有效手段,现研究的疫苗主要分为四大类:以金黄色葡萄菌全菌或部分菌体为疫苗,针对荚膜和黏附因子的疫苗、针对毒素和酶的疫苗和针对毒力因子表达调控蛋白的疫苗。 Staphylococcus aureus is one of the most common pathogens in and out of the hospital. The high infection rate and serious drug resistance cause great difficulties for the treatment. The vaccine is an effective way to prevent Staphylococcus aureus infection. The vaccines studied are mainly divided into four categories: whole or part of the bacteria Staphylococcus aureus vaccine, capsule and adhesion factor for the vaccine, toxins and enzymes Of vaccines and vaccines that target regulatory elements of virulence factors.