Y染色体上含有对睾丸决定和睾丸分化过程起重要作用的基因和基因家族。男性不育原因多样,大量研究表明Y染色体微缺失与男性不育的关系密切。与X染色体相比,由于Y染色体大部分不参与性染色体的重组,使它无论在大小还是基因数量上都出现了退化,未来的男性或许会面临生存的问题。现就Y染色体与男性不育、未来男性的命运进行综述。 The Y chromosome contains genes and gene families that play an important role in determining testicular and testicular differentiation. Many reasons for male infertility, a large number of studies have shown that Y chromosome microdeletions and male infertility are closely related. Compared with the X chromosome, because most of the Y chromosome is not involved in the recombination of sex chromosomes, it will degenerate both in size and in gene number, and future men may face the problem of survival. Now on the Y chromosome and male infertility, the future of the fate of men are reviewed.