为模拟研究天然氧载体血红蛋白和肌红蛋白的活性部位,合成了四种具有不同空间位阻的“栅栏”型铁(Ⅱ)卟啉络合物:中位-四-(α,α,α,α-邻-苯甲酰胺苯基)卟啉合铁(Ⅱ)、中位-四-(α,α,α,α-邻-苯乙酰胺苯基)卟啉合铁(Ⅱ)、中位-四-[α,α,α,α-邻-(3,5-二甲氧基)苯甲酰胺苯基]卟啉合铁(Ⅱ)和中位-四-[α,α,α,α-邻-(3,4,5-三甲氧基)苯甲酰胺苯基]卟啉合铁(Ⅱ)。 To simulate the active sites of natural oxygen carrier hemoglobin and myoglobin, four “fencing” iron (Ⅱ) porphyrin complexes with different steric hindrances were synthesized: , α-o -benzamidophenyl) porphyrinatoiron (Ⅱ), iron (Ⅱ), meso-tetrakis- (α, α, α, α-o-phenylacetamidophenyl) porphyrin Tetra - [α, α, α, α - o - (3,5 - dimethoxy) benzamide phenyl] , α-o- (3,4,5-trimethoxy) benzamide phenyl] porphyrin iron (II).