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抑制素(inhibin,INH)的发现,证实了除甾体激素外,在性腺还存在非甾体因素对垂体促性腺激素分泌进行反馈调节,因其参与女性卵泡发育调控及男性精子的发生,在辅助生育治疗中对卵巢功能评估、卵泡监测、预测无精症患者精子获得率等方面有重要意义,特介绍如下。 抑制素的来源 Mccullagh首次从牛睾丸中提取出一种水溶性物质,并发现可以抑制肥大的垂体去势细胞,称之为抑制素。以后随着对抑制素研究的不断深入,发现其广泛存在于人睾丸、附
The discovery of inhibin (INH) confirms that in addition to steroid hormones, non-steroidal factors exist in the gonads to feedback regulate the secretion of pituitary gonadotropin. Because of its involvement in the regulation of female follicles and the occurrence of male sperm, Assisted fertility treatment of ovarian function assessment, follicular monitoring, prediction of sperm motility in patients with azoospermic rate and so important, introduced as follows. The source of inhibin Mccullagh extracted a water-soluble substance from the bovine testicles for the first time and found that it can inhibit the hypertrophy of pituitary cells called inhibin. Later as the research on inhibin continues to deepen, found that it exists widely in human testicles, attached