论文部分内容阅读
目的观察中药“连紫汤”直肠滴入治疗小儿手足口病(HFMD)的临床疗效。方法将符合纳入标准的210例HFMD患儿,随机分为治疗组110例和对照组100例。治疗组予“连紫汤”20ml,直肠滴入,每日1次;对照组予重组人干扰素α-1b,1岁内患儿给予8μg,1～14岁10μg,肌内注射,每日1次,2组疗程均为5d。观察治疗前后临床症状、体温、皮疹、口腔黏膜疹、血常规等的变化。结果治疗组总有效率为97.3%,对照组总有效率为88.0%,治疗组总有效率优于对照组(P<0.05)。治疗组在退热时间、手足皮疹及口腔溃疡愈合方面均优于对照组,差异有统计学意义(P均<0.01)。结论中药“连紫汤”直肠滴入治疗HFMD疗效确切,且无不良反应。
Objective To observe the clinical efficacy of traditional Chinese medicine “Lian Zi Tang ” rectal infusion treatment of children with hand-foot-mouth disease (HFMD). Methods A total of 210 HFMD children who met the inclusion criteria were randomly divided into treatment group (n = 110) and control group (n = 100). The treatment group was treated with 20ml of “Zuizhitang” and rectally instilled once a day. In the control group, recombinant human interferon alpha-1b was given to 8μg, 1μg, 1 day, 2 groups of treatment are 5d. Before and after treatment to observe the clinical symptoms, body temperature, rash, oral mucosal rash, blood and other changes. Results The total effective rate was 97.3% in the treatment group and 88.0% in the control group. The total effective rate in the treatment group was better than that in the control group (P <0.05). The treatment group was better than the control group in the time of fever, hand-foot rash and oral ulcer healing, the difference was statistically significant (all P <0.01). Conclusion Traditional Chinese Medicine “Lian Zi Tang ” rectal infusion treatment of HFMD exact effect, and no adverse reactions.