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应用金盐治疗风湿性关节炎,是通过改变炎性细胞的作用而减少组织的破坏。本研究是探索金盐是否可缓解实验性边缘性牙周炎的组织破坏。实验动物为Squirrel猴四只,按每公斤体重5 mg肌肉注射硫代羟基丁二酸金钠(gold sodium thiomalate)共25mg/ml,每次间隔4日,为期12日,以使实验组动物血清中金盐达到治疗水平。而后,用滞留于下颌双尖牙缘龈,附着有菌斑的栓丝诱发实验性牙周炎。用四只动物作对照组,在与实验组相应的牙位诱发牙周炎,但不给金盐注射治疗。实验组动物的血清中的金盐维持治疗水平。在诱发牙周炎两周后处死两组全部动物,在系列切片上,对牙周炎的发展变化进行组织相评价,并就其结果进行统计学的
Gold salt treatment of rheumatoid arthritis, by changing the role of inflammatory cells and reduce tissue damage. This study explored whether gold salts can alleviate the tissue destruction of experimental marginal periodontitis. Experimental animals were four Squirrel monkeys, intramuscular injection of gold sodium thiomalate 25mg / ml intramuscularly at 5 mg / kg body weight for 4 days, a period of 12, so that the experimental group of animal serum The gold salt to the treatment level. Then, with the stay in the mandibular double-edge gums, plaque attached to the filament induced experimental periodontitis. Four animals were used as the control group, periodontitis was induced in the corresponding tooth position of the experimental group, but the injection of gold salt was not given. The gold salts in the serum of experimental animals maintained the therapeutic level. Two weeks after the onset of periodontitis, all animals were sacrificed, and histological evaluation of the development and progression of periodontitis was performed on the series of sections, and the results were statistically analyzed