目的　对金石颗粒减低鼻咽癌放射反应的作用进行研究 ,为临床提供有效的治疗药物。方法　将 90例鼻咽癌首次根治性放射治疗患者随机均衡地分为治疗 1组 (金石颗粒剂加放疗 )、治疗 2组 (鼻咽清毒剂加放疗 )、对照组 (安慰剂加放疗 ) 3组 ,各 30例。结果　①治疗 1组对鼻咽癌的缓解率为 93 33%、放疗完成率为 96 6 7%,Karnofsky评分的提高稳定率为 90 0 0 %,分别高于其他两组 (P <0 0 5、P <0 0 1) ;②治疗 1组出现的放射反应程度明显轻于其他两组 (P <0 0 5、P <0 0 1) ;其外周血象得到稳定 (P >0 0 5 ) ,且其稳定性优于其他两组 (P <0 0 5、P <0 0 1)。结论　金石颗粒剂有显著的减毒作用 ,可改善生活质量 ,配合放疗对鼻咽癌有较好的治疗作用。 Objective To study the effect of Jinshi granule in reducing radiation reaction of nasopharyngeal carcinoma and provide effective therapeutic drug for clinical use. Methods Ninety patients with nasopharyngeal carcinoma for the first time undergoing radical radiotherapy were randomly divided into treatment group 1 (Jinshi granule plus radiotherapy), treatment 2 (nasopharyngeal detoxification plus radiotherapy), and control group (placebo plus radiotherapy) 3 Group, each 30 cases. Results ① The remission rate of NPC was 93.33%, the complete radiotherapy rate was 96.67%, and the Karnofsky score was 90.0%, which was higher than the other two groups (P <0.05) , P <0.01); ② The radiological response in treatment group 1 was significantly lighter than that in the other two groups (P <0.05, P <0.01); the peripheral blood was stable (P> 0.05) Its stability was better than the other two groups (P <0.05, P <0.01). Conclusion Jinshi granule has a significant attenuation effect, can improve the quality of life, with radiotherapy for nasopharyngeal carcinoma have a better therapeutic effect.