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10名健康成年男性受试者禁食一夜后口服800mg雷尼替丁,2小时半后,插入附有两个气囊的导管系统。这两个气囊充气后分别堵住食管中段和食管-胃结合区,于是,对这两个气囊之间隔开来的下段10cm食管进行研究。此外,嘱受试者不下咽唾液,并不断从口腔内和食管中段气囊上吸引,以尽可能防止唾液沾染下段食管的试验液;还在胃囊内注少量颜色标示剂酚红,以明确有无返流的胃内容物沾染食管试验液,一旦沾染,
Ten healthy adult male subjects were given 800 mg of ranitidine orally overnight after fasting, and two hours and a half later, a catheter system with two balloons inserted. The two balloons were inflated, respectively, blocking the middle of the esophagus and esophageal - gastric junction area, so the next two 10cm interval between the two balloon esophageal research. In addition, subjects were instructed not to swallow saliva, and continue to be from the mouth and esophageal airbags on the balloon to attract as much as possible to prevent the lower esophageal saliva contaminated test fluid; also in the stomach capsule note a small amount of color-labeled phenol red to clear No reflux of stomach contents contaminated esophageal test fluid, once contaminated,