中性粒细胞明胶酶相关脂质运载蛋白(NGAL)是一个25×10~3的分泌蛋白,最先在1993年被Kjeldsen L发现存在于人类中性粒细胞的特殊颗粒中。NGAL在小鼠身上的同源基因表达蛋白24p3也已经被确定,它可以诱导正常血细胞的凋亡,包括小鼠原始骨髓细胞、脾细胞、胸腺细胞、人类中性粒细胞以及外周血淋巴细胞。另外,很多以小鼠为实验模型的实验数据也证实其作用机制。本文主要介绍NGAL及其鼠同源基因与慢性粒细胞性白血病的关系。 Neutrophil gelatinase-associated lipocalin (NGAL) is a 25 × 10 -3 secretory protein that was first found by Kjeldsen L in 1993 in specific particles of human neutrophils. The homologous gene expression protein 24p3 ​​of NGAL in mice has also been identified, which can induce apoptosis in normal blood cells including mouse primary bone marrow cells, spleen cells, thymocytes, human neutrophils, and peripheral blood lymphocytes. In addition, many experimental data in mice as experimental model also confirmed its mechanism of action. This article describes the NGAL and its murine homologous genes and chronic myeloid leukemia relationship.