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本文对２２例食管鳞癌患者联合化疗前后活检或手术标本进行核仁形成区（ＡｇＮＯＲｓ）染色，比较同一患者化疗前后癌细胞ＡｇＮＯＲｓ颗粒数，分析颗粒数变化与临床化疗效果的关系。结果显示１２例化疗有效（ＣＲ＋ＰＲ）者ＡｇＮＯＲｓ颗粒数均明显减少（Ｐ＜０．００１），化疗无效（ＳＤ＋ＰＤ）者颗粒数都无明显变化（Ｐ＞０．０５）。提示同一患者化疗前后癌细胞ＡｇＮＯＲｓ颗粒数变化可做为评价疗效的一个病理学指标。
In this paper, 22 cases of esophageal squamous cell carcinoma patients before and after chemotherapy combined with chemotherapy for nucleolar formation area (AgNORs) staining, compare the same patients before and after chemotherapy cancer cells AgNORs number of particles, analyze the relationship between changes in particle number and the clinical efficacy of chemotherapy. The results showed that the number of AgNORs particles in 12 patients with chemotherapy-effective (CR+PR) was significantly reduced (P<0.001), and there was no significant change in the number of particles in chemotherapy-ineffective (SD+PD) patients (P>0.05). It is suggested that the change of the number of AgNORs in the same patient before and after chemotherapy can be used as a pathological indicator to evaluate the efficacy.