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激素不反应症的概念 所谓激素不反应症是指激素的质和量正常,而靶细胞或激素的作用机制障碍而引起的疾病。即生物对内源性或外源性激素的不反应状态或反应低下状态。1942年Albright报告假性甲状旁腺机能低下症(Pseudohy-poparathyrodism),本症临床上、生化表现上与真性甲状旁腺机能低下症无区别。但以PTH治疗无效,不能纠正其生化异常。本症手术探查证明甲状旁腺正常,甚至增生。当时推测其原因是组织对PTH的抵抗状态,即不反应状态,从那时至今,多种激素的不反应症相继报告。现在已知几乎所有的激素都存在不反应症。
The concept of hormone non-response The so-called hormone non-response refers to the normal quality and quantity of hormones, and target cells or hormones caused by obstacles in the mechanism of disease. That biological endogenous or exogenous hormones in the state of non-reaction or reaction state. 1942 Albright reported pseudo-hypoparathyroidism (Pseudohy-poparathyrodism), the disease clinically, biochemical performance and true hypoparathyroidism is no difference. However, the treatment of PTH is invalid, can not correct its biochemical abnormalities. Surgical exploration proved normal parathyroid or even hyperplasia. It was speculated that the reason is the organization of PTH resistance status, that is, non-responsive state, since then, a variety of hormone non-responsiveness have been reported. It is now known that almost all hormones are non-responsive.