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目的总结我院ABO新生儿溶血病诊断经验。方法选取712例新生儿黄疸患儿及母亲血样,常规鉴定ABO血型、患儿血清学三项试验、母亲血清IgG抗-A(B)抗体效价,同时对产妇年龄、流产次数、新生儿黄疸发生的时间进行调查。结果明确ABO母婴血型不合新生儿溶血病78例,产妇年龄分布30岁以下共63例(80.8%),有流产史共68例(87.2%),新生儿黄疸发生3天内发生共51例(65.4%)。其中O-A型48例,O-B型30例,发病患儿母亲血清IgG抗-A(B)抗体效价1:16共0例(0%),1:32-64共9例(11.5%),1:128-512共56例(72.8%),≥1:1024共13例(16.7%)。新生儿溶血病血清学放散试验阳性78例(100%),游离试验阳性50例(64.1%),直抗试验阳性30例(38.5%)。结论为预防ABO新生儿溶血病的发生,对孕妇做产前的ABO血型和血清IgG抗-A(B)抗体效价筛查极有必要,尤其是曾有生产史、流产史的孕妇,同时及时做新生儿黄疸的检查。
Objective To summarize the diagnostic experience of neonatal hemolytic disease in our hospital. Methods Blood samples of 712 neonates with jaundice and their mothers were selected and routinely identified as ABO blood type, three serological tests in children and the serum IgG anti-A (B) antibody titers of maternal serum. The maternal age, number of miscarriage, neonatal jaundice Time to investigate. The results of clear ABO maternal and infant blood group 78 cases of neonatal hemolytic disease, maternal age distribution under the age of 63 in 63 cases (80.8%), a total of 68 cases of abortion (87.2%), neonatal jaundice occurred within 3 days a total of 51 cases 65.4%). Among them, there were 48 cases of OA type and 30 cases of OB type. The serum IgG anti-A (B) antibody titer of 0: 1 in 1:16 (11.5% There were 56 cases (72.8%) in 1: 128-512 and 13 cases (16.7%) in ≥1: 1024. 78 cases (100%) had seropositivity for neonatal hemolytic disease, 50 (64.1%) were positive for free test and 30 (38.5%) for positive test. Conclusion In order to prevent the occurrence of hemolytic disease in neonates with ABO, prenatal ABO blood group and serum IgG anti-A (B) antibody titer screening is very necessary for pregnant women, especially pregnant women who have history of production and miscarriage history Timely neonatal jaundice check.